THIS MEDICATION CAN CAUSE HARM TO YOUR BABY:
Despite limited evidence in human pregnancy, bortezomib is expected to cause harm to the developing baby. Bortezomib should not be used during pregnancy or while breastfeeding.
What is bortezomib?
Bortezomib is a toxic medication used to treat cancers such as multiple myeloma.
What is bortezomib used to treat?
Bortezomib is a prescription medication used for mantle cell lymphoma and multiple myeloma after a prior therapy has been tried.
How does bortezomib work?
Bortezomib is a type of anticancer medication known as proteasome inhibitor. Bortezomib interferes with cellular enzymes known as proteasomes to cause cancer cell death.
If I am taking bortezomib, can it harm my baby?
Bortezomib is expected to cross the human placenta to reach the developing baby. Animal and human studies have linked bortezomib to death and negative effects on growth in the developing baby.
If I am taking bortezomib and become pregnant, what should I do?
It is recommended to use contraception to avoid pregnancy while on bortezomib therapy and for at least 2 months after stopping therapy. Pregnancy testing is performed in women prior to starting this medication. If the medication is required during pregnancy, the woman must be advised on the safety risks. If the medication is not required, it is best to avoid taking bortezomib during pregnancy to prevent harm to the baby. If a woman becomes pregnant while on bortezomib, the risks of this medication should be discussed.
If I am taking bortezomib, can I safely breastfeed my baby?
Bortezomib is expected to pass into human breast milk, although how much of the medication infants are exposed to is unknown. It is recommended to avoid breastfeeding while taking this medication and for at least 2 months after stopping this medication.
If I am taking bortezomib, will it be more difficult to get pregnant?
Animal studies have found that bortezomib can cause degeneration of the ovaries and testes with exposure to doses lower than human doses.
If I am taking bortezomib, what should I know?
Bortezomib is a toxic medication. It is recommended to avoid this medication during pregnancy unless needed. Women who take bortezomib after delivery should avoid breastfeeding.
If I am taking any medication, what should I know?
This report provides a summary of available information about the use of proteasome inhibitors during pregnancy and breastfeeding. Content is from the product label unless otherwise indicated.
You may find Pregistry's expert reports about oncology here, reports about the individual medications used to treat cancer here, and a report about cancer here. Additional information can also be found in the resources below.
For more information about bortezomib during and after pregnancy, contact http://www.womenshealth.gov/ (800-994-9662 [TDD: 888-220-5446]) or check the following link:
Velcade: Velcade Prescribing Information