This medication is considered to have a low risk when used during pregnancy. It should not be used with methotrexate.
What is Infliximab?
Infliximab stops chronic inflammation in the body that causes autoimmune diseases such as rheumatoid arthritis.
What is Infliximab used to treat?
Infliximab is a prescription medication used to treat rheumatoid arthritis, Crohn’s disease, ulcerative colitis, ankylosing spondylitis, and psoriasis.
How does infliximab work?
Infliximab is an antibody that blocks the production of certain inflammatory chemicals in the body that cause autoimmune disease.
If I am taking infliximab, can it harm my baby?
The World Congress of Gastroenterology finds that infliximab is associated with low risk to the developing baby when used during conception in men or during the first 2 trimesters of pregnancy in women. Infliximab does cross the human placenta after the first trimester, but no studies have identified adverse effects associated with maternal use during pregnancy. Some studies have suggested that infliximab is associated with an increased risk of prematurity and low birth weight, but no correlation has been proven. The effect of infliximab on long-term infant immune function is unknown. There is a study that collects data from pregnancies exposed to infliximab: MotherToBaby Autoimmune Diseases Study. Your doctor can enroll you in this study if you take infliximab during pregnancy.
Infliximab should only be used for treatment in pregnant women who need the medication. It is recommended to limit the use of infliximab to the first 30 days of pregnancy. Infants exposed to infliximab in the womb may require a 6 month waiting period before administration of live vaccines. For women who are also taking methotrexate, it is important to speak with your doctor to decide if you should continue taking the medication.
If I am taking infliximab, can I safely breastfeed my baby?
The World Congress of Gastroenterology has stated that infliximab is safe during breastfeeding; however, the medication’s packaging states that it should not be used by breastfeeding women. It is important to talk to your doctor to decide if you should continue on infliximab during breastfeeding.
If I am taking infliximab, will it be more difficult to get pregnant?
The World Congress of Gastroenterology has stated that infliximab can be used in men or women during conception. It is unknown if it affects reproduction in humans; available recommendations are based on animal studies of a similar antibody. A small sample of men exposed to infliximab found no consistent negative effect on male sperm.
If I am taking infliximab, what should I know?
Although infliximab may be associated with a small risk of side effects in the developing baby, serious birth defects are not increased with its use during pregnancy.
If I am taking any medication, what should I know?
This report provides a summary of available information about the use of Remicade during pregnancy and breastfeeding. Content is from the product label unless otherwise indicated.
You may find Pregistry's expert reports about autoimmune diseases here, reports about the individual medications used to treat immune disorders here, and a report about psoriasis here. Additional information can also be found in the resources below.
Janssen: Remicade Prescribing Information