Other Conditions & Exposures

Expert reports about Other Conditions & Exposures


INFORMATION FOR WOMEN WHO HAVE AMYLOIDOSIS DURING PREGNANCY OR BREASTFEEDING

                                                                                                                                                

What is amyloidosis during pregnancy?

Amyloidosis is a group of conditions characterized by the buildup of misfolded proteins within body tissues, outside of body cells. Normally, proteins should be dissolved in the fluid that surrounds the cells (extracellular fluid), but when proteins fold in certain ways that they’re not supposed to fold, they become less soluble. The result is sheets of fibrous material called amyloid, which means “starch-like, because, when the 19th-century pathologist Rudolf Virchow discovered it, he thought he saw a type of carbohydrate. Today, however, we know not only that amyloid is protein, but that numerous different proteins can form it, and there are two ways that this can happen. One way is that there is a mistake in the sequence of protein building blocks, called amino acids. This can happen in a variety of conditions, and it affects how the protein folds up into the 3-dimensional structure that determines its function.


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